Human Monoclonal Antibody Reactivity With Human Leukocyte Antigen Class I Epitopes Defined by Pairs of Mismatched Eplets and Self-Eplets | Zendy

Marilyn Marrari | Zendy; Justin Mostecki | Zendy; Arend Mulder | Zendy; Frans H.J. Claas | Zendy; I. Balazs | Zendy; René J. Duquesnoy | Zendy

Open Access

Human Monoclonal Antibody Reactivity With Human Leukocyte Antigen Class I Epitopes Defined by Pairs of Mismatched Eplets and Self-Eplets

Author(s) -

Marilyn Marrari,

Justin Mostecki,

Arend Mulder,

Frans H.J. Claas,

I. Balazs,

René J. Duquesnoy

Publication year - 2010

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3182007b74

Subject(s) - epitope , antigen , monoclonal antibody , antibody , human leukocyte antigen , immunogenicity , immunology , biology , context (archaeology) , virology , paleontology

Humoral sensitization affects transplant outcome, and it is now apparent that human leukocyte antigen (HLA) antibodies are specific for epitopes rather than antigens. Such epitopes can be structurally defined by HLAMatchmaker, an algorithm that considers eplets as critical elements of epitopes recognized by alloantibodies. This study addressed the question how mismatched HLA antigens induce specific antibodies in context with eplet differences with the antibody producer.

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