Open AccessUrinary Cell Levels of mRNA for OX40, OX40L, PD-1, PD-L1, or PD-L2 and Acute Rejection of Human Renal Allografts
Author(s) -
Cheguevara Afaneh,
Thangamani Muthukumar,
Michelle Lubetzky,
Ruchuang Ding,
Catherine Snopkowski,
Vijay Kumar Sharma,
Surya V. Seshan,
Darshana Dadhania,
Joseph E. Schwartz,
Manikkam Suthanthiran
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181ffbadd
Subject(s) - urinary system , foxp3 , messenger rna , medicine , transplantation , biomarker , biopsy , creatinine , receiver operating characteristic , kidney transplantation , immune system , immunology , urology , biology , gene , biochemistry
The positive costimulatory proteins OX40 and OX40L and negative regulatory proteins programmed death (PD)-1, PD ligand 1, and PD ligand 2 have emerged as significant regulators of acute rejection in experimental transplantation models.