Open AccessContribution of Toll-Like Receptor Activation to Lung Damage After Donor Brain Death
Author(s) -
Anthony J. Rostron,
David M.W. Cork,
Vassilios S. Avlonitis,
Andrew J. Fisher,
John Dark,
John A. Kirby
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181eefe02
Subject(s) - medicine , tlr4 , receptor , tlr2 , transplantation , lung transplantation , immunology , endocrinology
Donor brain death is the first injurious event that can produce inflammatory dysfunction after pulmonary transplantation. This study was designed to determine whether stimulation of the toll-like receptor (TLR) system contributes to the changes produced by brain death.