Open AccessTransplantation of Reprogrammed Embryonic Stem Cells Improves Visual Function in a Mouse Model for Retinitis Pigmentosa
Author(s) -
Nan-Kai Wang,
Joaquin Tosi,
J. M. Kasanuki,
Chun Liang Chou,
Jian Kong,
Nancy L. Parmalee,
Katherine J. Wert,
Rando Allikmets,
ChaoLun Lai,
ChungLiang Chien,
Takayuki Nagasaki,
Chyuan Sheng Lin,
Stephen H. Tsang
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181d45a61
Subject(s) - retinitis pigmentosa , transplantation , stem cell , biology , embryonic stem cell , retinal , retina , retinal degeneration , microbiology and biotechnology , retinal pigment epithelium , gene therapy of the human retina , pathology , medicine , neuroscience , genetics , biochemistry , gene
To study whether C57BL/6J-Tyr/J (C2J) mouse embryonic stem (ES) cells can differentiate into retinal pigment epithelial (RPE) cells in vitro and then restore retinal function in a model for retinitis pigmentosa: Rpe65/Rpe65 C57BL6 mice.