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Transplantation of Reprogrammed Embryonic Stem Cells Improves Visual Function in a Mouse Model for Retinitis Pigmentosa
Author(s) -
NanKai Wang,
Joaquin Tosi,
J. M. Kasanuki,
Chai Lin Chou,
Jian Kong,
Nancy L. Parmalee,
Katherine J. Wert,
Rando Allikmets,
ChiChun Lai,
C. L. Chien,
Takayuki Nagasaki,
Chyuan-Sheng Lin,
Stephen H. Tsang
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181d45a61
Subject(s) - retinitis pigmentosa , transplantation , stem cell , biology , embryonic stem cell , retinal , retina , retinal degeneration , microbiology and biotechnology , retinal pigment epithelium , gene therapy of the human retina , pathology , medicine , neuroscience , genetics , biochemistry , gene
To study whether C57BL/6J-Tyr/J (C2J) mouse embryonic stem (ES) cells can differentiate into retinal pigment epithelial (RPE) cells in vitro and then restore retinal function in a model for retinitis pigmentosa: Rpe65/Rpe65 C57BL6 mice.

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