Induction of B-Cell Immune Tolerance by Antigen-Modified Cytotoxic T Lymphocytes | Zendy

Phuong Nguyen | Zendy; Terrence L. Geiger | Zendy

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Induction of B-Cell Immune Tolerance by Antigen-Modified Cytotoxic T Lymphocytes

Author(s) -

Phuong Nguyen,

Terrence L. Geiger

Publication year - 2010

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3181ca9048

Subject(s) - ctl* , cytotoxic t cell , immune tolerance , immunology , biology , immune system , t cell , antigen , adoptive cell transfer , microbiology and biotechnology , cd8 , in vitro , biochemistry

Third-party-specific cytotoxic T lymphocytes (CTL), or veto CTL, are being assessed as a cellular therapeutic for the induction of T-cell tolerance during transplantation. Conceptually, veto cell-expressed antigens (Ags) may induce B-cell immune responses, and this may have deleterious consequences. Whether veto cells induce immunity, tolerance, or are ignored by B lymphocytes has, however, not been addressed.

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