Open AccessInduction of B-Cell Immune Tolerance by Antigen-Modified Cytotoxic T Lymphocytes
Author(s) -
Phuong Nguyen,
Terrence L. Geiger
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181ca9048
Subject(s) - ctl* , cytotoxic t cell , immune tolerance , immunology , biology , immune system , t cell , antigen , adoptive cell transfer , microbiology and biotechnology , cd8 , in vitro , biochemistry
Third-party-specific cytotoxic T lymphocytes (CTL), or veto CTL, are being assessed as a cellular therapeutic for the induction of T-cell tolerance during transplantation. Conceptually, veto cell-expressed antigens (Ags) may induce B-cell immune responses, and this may have deleterious consequences. Whether veto cells induce immunity, tolerance, or are ignored by B lymphocytes has, however, not been addressed.