Open AccessNOD-scid IL2rγnull Mouse Model of Human Skin Transplantation and Allograft Rejection
Author(s) -
Waldemar J. Racki,
Laurence Covassin,
Michael A. Brehm,
Stephen Pino,
Ronald A. Ignotz,
Raymond M. Dunn,
Joseph Laning,
Susannah Graves,
Aldo A. Rossini,
Leonard D. Shultz,
Dale L. Greiner
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181c90242
Subject(s) - humanized mouse , transplantation , immune system , human skin , nod , inflammation , wound healing , immunology , peripheral blood mononuclear cell , severe combined immunodeficiency , medicine , pathology , biology , surgery , diabetes mellitus , biochemistry , gene , in vitro , genetics , endocrinology
Transplantation of human skin on immunodeficient mice that support engraftment with functional human immune systems would be an invaluable tool for investigating mechanisms involved in wound healing and transplantation. Nonobese diabetic (NOD)-scid interleukin-2 gamma chain receptor (NSG) readily engraft with human immune systems, but human skin graft integrity is poor. In contrast, human skin graft integrity is excellent on CB17-scid bg (SCID.bg) mice, but they engraft poorly with human immune systems.