Open AccessAcute Cardiac Allograft Rejection by Directly Cytotoxic CD4 T Cells: Parallel Requirements for Fas and Perforin
Author(s) -
Todd J. Grazia,
Robert J. Plenter,
Sarah M. Weber,
Helen M. Lepper,
Francisco Victorino,
Martin R. Zamora,
Biagio A. Pietra,
Ronald G. Gill
Publication year - 2010
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181be6bc7
Subject(s) - perforin , cytotoxic t cell , fas ligand , t cell , cytolysis , immunology , biology , cd8 , t lymphocyte , immune system , microbiology and biotechnology , apoptosis , in vitro , programmed cell death , biochemistry
CD4 T cells can suffice as effector cells to mediate primary acute cardiac allograft rejection. Although CD4 T cells can readily kill appropriate target cells in vitro, the corresponding role of such cytolytic activity for mediating allograft rejection in vivo is unknown. Therefore, we determined whether the cytolytic effector molecules perforin (PFP) and/or FasL (CD95L) were necessary for CD4 T cell-mediated rejection in vivo.