Open AccessGITR Blockade Facilitates Treg Mediated Allograft Survival
Author(s) -
Samsher Sonawane,
James I. Kim,
Major K. Lee,
SeoungHoon Lee,
Patrick E. Duff,
Daniel J. Moore,
MohMoh Lian,
Shaoping Deng,
Yongwon Choi,
Heidi Yeh,
Andrew J. Caton,
James F. Markmann
Publication year - 2009
Publication title -
transplantation
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181ba6f85
Subject(s) - immunology , immune system , innate immune system , inflammation , antigen , immune tolerance , effector , tumor necrosis factor alpha , medicine , adoptive cell transfer , transplantation , cancer research , t cell
Many models of transplant tolerance have been found to depend on the induction of regulatory T cells (Tregs). Innate immune signals are known to suppress Tregs thereby augmenting immunity by abrogating Treg function. Such signals may also provide a barrier to transplantation tolerance mediated by Tregs. A number of cell surface molecules expressed by Tregs have been found to inhibit Treg activity, the best characterized of which is the glucocorticoid-induced tumor necrosis factor receptor-related (GITR) protein.