Open AccessIslet Grafting and Imaging in a Bioengineered Intramuscular Space
Author(s) -
Piotr Witkowski,
Hugo Sondermeijer,
Mark A. Hardy,
David C. Woodland,
Keagan Lee,
Govind Bhagat,
Kajetan Witkowski,
Fiona See,
Abbas Rana,
Antonella Maffei,
Silviu Itescu,
Paul E. Harris
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181ba2e87
Subject(s) - islet , medicine , transplantation , neovascularization , positron emission tomography , pathology , angiogenesis , surgery , nuclear medicine , insulin
Because the hepatic portal system may not be the optimal site for islet transplantation, several extrahepatic sites have been studied. Here, we examine an intramuscular transplantation site, bioengineered to better support islet neovascularization, engraftment, and survival, and we demonstrate that at this novel site, grafted beta cell mass may be quantitated in a real-time noninvasive manner by positron emission tomography (PET) imaging.