B Cells Are Dispensable for Neonatal Transplant Tolerance Induction | Zendy

Wendy E. Walker | Zendy; Daniel R. Goldstein | Zendy

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B Cells Are Dispensable for Neonatal Transplant Tolerance Induction

Author(s) -

Wendy E. Walker,

Daniel R. Goldstein

Publication year - 2009

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3181b6eca2

Subject(s) - immunology , spleen , b cell , biology , stimulation , transplantation , immune tolerance , bruton's tyrosine kinase , receptor , medicine , immune system , antibody , endocrinology , genetics , tyrosine kinase

Prior studies have demonstrated that neonatal B cells possess unique immunoregulatory properties. Specifically, neonatal B-1 cells produce interleukin (IL)-10 in response to toll-like receptor stimulation; this modulates innate and adaptive alloimmune responses. Here, we examine whether this process plays a critical role in neonatal transplant tolerance induction.

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