Open AccessB Cells Are Dispensable for Neonatal Transplant Tolerance Induction
Author(s) -
Wendy E. Walker,
Daniel R. Goldstein
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181b6eca2
Subject(s) - immunology , spleen , b cell , biology , stimulation , transplantation , immune tolerance , bruton's tyrosine kinase , receptor , medicine , immune system , antibody , endocrinology , genetics , tyrosine kinase
Prior studies have demonstrated that neonatal B cells possess unique immunoregulatory properties. Specifically, neonatal B-1 cells produce interleukin (IL)-10 in response to toll-like receptor stimulation; this modulates innate and adaptive alloimmune responses. Here, we examine whether this process plays a critical role in neonatal transplant tolerance induction.