Dissociation Between Peripheral Blood Chimerism and Tolerance to Hindlimb Composite Tissue Transplants: Preferential Localization of Chimerism in Donor Bone | Zendy

Dina Rahhal | Zendy; Hong Xu | Zendy; Wei-Chao Huang | Zendy; Shengli Wu | Zendy; Yujie Wen | Zendy; Yiming Huang | Zendy; Suzanne T. Ildstad | Zendy

Open Access

Dissociation Between Peripheral Blood Chimerism and Tolerance to Hindlimb Composite Tissue Transplants: Preferential Localization of Chimerism in Donor Bone

Author(s) -

Dina Rahhal,

Hong Xu,

Wei-Chao Huang,

Shengli Wu,

Yujie Wen,

Yiming Huang,

Suzanne T. Ildstad

Publication year - 2009

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3181b47cfa

Subject(s) - total body irradiation , bone marrow , chimera (genetics) , haematopoiesis , immunology , medicine , transplantation , transplantation chimera , monoclonal antibody , immune tolerance , antibody , immune system , biology , stem cell , chemotherapy , hematopoietic cell , cyclophosphamide , microbiology and biotechnology , biochemistry , gene

Mixed chimerism induces donor-specific tolerance to composite tissue allotransplants (CTAs). In the present studies, we used a nonmyeloablative conditioning approach to establish chimerism and promote CTA acceptance.

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