Open AccessDissociation Between Peripheral Blood Chimerism and Tolerance to Hindlimb Composite Tissue Transplants: Preferential Localization of Chimerism in Donor Bone
Author(s) -
Dina Rahhal,
Hong Xu,
Wei-Chao Huang,
Shengli Wu,
Yujie Wen,
Yiming Huang,
Suzanne T. Ildstad
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181b47cfa
Subject(s) - total body irradiation , bone marrow , chimera (genetics) , haematopoiesis , immunology , medicine , transplantation , transplantation chimera , monoclonal antibody , immune tolerance , antibody , immune system , biology , stem cell , chemotherapy , hematopoietic cell , cyclophosphamide , microbiology and biotechnology , biochemistry , gene
Mixed chimerism induces donor-specific tolerance to composite tissue allotransplants (CTAs). In the present studies, we used a nonmyeloablative conditioning approach to establish chimerism and promote CTA acceptance.