Establishment of Long-Term Tolerance to SRBC in Dogs by Recombinant Canine CTLA4-Ig | Zendy

Scott S. Graves | Zendy; Diane Stone | Zendy; Carol Loretz | Zendy; Laura Peterson | Zendy; Jeannine S. McCune | Zendy; Marco Mielcarek | Zendy; Rainer Storb | Zendy

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Establishment of Long-Term Tolerance to SRBC in Dogs by Recombinant Canine CTLA4-Ig

Author(s) -

Scott S. Graves,

Diane Stone,

Carol Loretz,

Laura Peterson,

Jeannine S. McCune,

Marco Mielcarek,

Rainer Storb

Publication year - 2009

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3181ae3285

Subject(s) - antibody , antigen , immunology , monoclonal antibody , microbiology and biotechnology , immune system , biology , medicine

Blockade of the CD28 costimulatory molecule by recombinant human cytotoxic T lymphocyte (CTL)-associated antigen (CTLA4)-Ig or CD40-CD154 interaction with the monoclonal antibody 5C8 together with donor-specific transfusion led to enhanced engraftment in the canine model of dog leukocyte antigen (DLA)-identical marrow transplantation after 1 Gy total body irradiation. To reduce or eliminate total body irradiation conditioning regimens, we have sought to develop canine specific reagents.

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