Open AccessEstablishment of Long-Term Tolerance to SRBC in Dogs by Recombinant Canine CTLA4-Ig
Author(s) -
Scott S. Graves,
Diane Stone,
Carol Loretz,
Laura Peterson,
Jeannine S. McCune,
Marco Mielcarek,
Rainer Storb
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181ae3285
Subject(s) - antibody , antigen , immunology , monoclonal antibody , microbiology and biotechnology , immune system , biology , medicine
Blockade of the CD28 costimulatory molecule by recombinant human cytotoxic T lymphocyte (CTL)-associated antigen (CTLA4)-Ig or CD40-CD154 interaction with the monoclonal antibody 5C8 together with donor-specific transfusion led to enhanced engraftment in the canine model of dog leukocyte antigen (DLA)-identical marrow transplantation after 1 Gy total body irradiation. To reduce or eliminate total body irradiation conditioning regimens, we have sought to develop canine specific reagents.