Real-Time Bioluminescence Imaging of Macroencapsulated Fibroblasts Reveals Allograft Protection in Rhesus Monkeys (Macaca mulatta) | Zendy

Alice F. Tarantal | Zendy; C Chang I. Lee | Zendy; Pamela ItkinAnsari | Zendy

Open Access

Real-Time Bioluminescence Imaging of Macroencapsulated Fibroblasts Reveals Allograft Protection in Rhesus Monkeys (Macaca mulatta)

Author(s) -

Alice F. Tarantal,

C Chang I. Lee,

Pamela ItkinAnsari

Publication year - 2009

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e3181a9ee6c

Subject(s) - bioluminescence imaging , luciferase , immunosuppression , transplantation , immune system , bioluminescence , cell , medicine , animal model , microbiology and biotechnology , pathology , biology , immunology , andrology , cancer research , cell culture , surgery , transfection , genetics , ecology

Encapsulation of cells has the potential to eliminate the need for immunosuppression for cellular transplantation. Recently, the TheraCyte device was shown to provide long-term immunoprotection of murine islets in a mouse model of diabetes. In this report, translational studies were undertaken using skin fibroblasts from an unrelated rhesus monkey donor that were transduced with an HIV-1-derived lentiviral vector expressing firefly luciferase permitting the use of bioluminescence imaging (BLI) to monitor cell survival over time and in a noninvasive manner.

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