Open AccessCytoplasmic Inheritance of Transplantation Antigens in Animals Produced by Nuclear Transfer
Author(s) -
John S. Hanekamp,
Masayoshi Okumi,
Aseda Tena,
Scott Arn,
Kazuhiko Yamada,
David H. Sachs
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181a9ed5b
Subject(s) - biology , hypervariable region , mitochondrial dna , genetics , haplotype , transplantation , non mendelian inheritance , histocompatibility , nuclear dna , major histocompatibility complex , antigen , nuclear gene , gene , genotype , human leukocyte antigen , medicine , surgery
Nuclear transfer has been used as a means of selectively modifying the mammalian genome. One possible consequence of this technology is that the oocytes used in nuclear transfer may provide additional antigens by cytoplasmic inheritance of maternally derived, mitochondrial DNA (mtDNA). These studies examine the potential consequences of such inheritance in a large animal transplantation model.