Open AccessProtective Effects of Ezrin on Cold Storage Preservation Injury in the Pig Kidney Proximal Tubular Epithelial Cell Line (LLC-PK1)
Author(s) -
Tian Tian,
Susanne L. Lindell,
Scott C. Henderson,
Martin J. Mangino
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181a43f18
Subject(s) - ezrin , kidney , epithelium , cold storage , line (geometry) , microbiology and biotechnology , chemistry , andrology , biology , cell , medicine , pathology , biochemistry , geometry , mathematics , cytoskeleton , horticulture
Renal damage caused by cold preservation and warm reperfusion has been well documented and involves tissue edema, cell swelling, ATP depletion, calcium toxicity, and oxidative stress. However, more common proximal mechanisms have not been identified, which may limit the development of effective clinical treatment strategies. Previous work indicates that many cytoskeletal structures are affected by cold preservation and reperfusion, including membrane-rich ezrin-associated complexes. The aim of this study was to investigate whether the sublamellar cytoskeletal protein ezrin is causally involved in cold preservation injury in renal tubule epithelial cells.