Open AccessMechanisms of Transplantation Tolerance in Animals and Humans
Author(s) -
Megan Sykes
Publication year - 2009
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e3181a2a6b8
Subject(s) - immune tolerance , transplantation , medicine , clinical trial , hematopoietic cell , immunology , hematopoietic stem cell transplantation , immunologic tolerance , immune system , transplantation chimera , intensive care medicine , haematopoiesis , biology , stem cell , genetics
Donor-specific immune tolerance would avoid the toxicities of chronic immunosuppressive therapies while preventing graft rejection. Hematopoietic cell transplantation has shown preliminary success for intentional tolerance induction in pilot clinical trials. The mechanisms of tolerance in these trials and the animal studies leading up to them are discussed.