Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies | Zendy

Seunghee Lee | Zendy; Ergeng Hao | Zendy; Alexei Y. Savinov | Zendy; Ifat Geron | Zendy; Alex Y. Strongin | Zendy; Pamela ItkinAnsari | Zendy

Open Access

Human β-cell Precursors Mature Into Functional Insulin-producing Cells in an Immunoisolation Device: Implications for Diabetes Cell Therapies

Author(s) -

Seunghee Lee,

Ergeng Hao,

Alexei Y. Savinov,

Ifat Geron,

Alex Y. Strongin,

Pamela ItkinAnsari

Publication year - 2009

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31819c86ea

Subject(s) - immunosuppression , islet , transplantation , progenitor cell , nod mice , medicine , nod , stem cell , diabetes mellitus , pancreatic islets , insulin , immunology , type 1 diabetes , biology , endocrinology , microbiology and biotechnology

Islet transplantation is limited by the need for chronic immunosuppression and the paucity of donor tissue. As new sources of human beta-cells are developed (e.g., stem cell-derived tissue), transplanting them in a durable device could obviate the need for immunosuppression, while also protecting the patient from any risk of tumorigenicity. Here, we studied (1) the survival and function of encapsulated human beta-cells and their progenitors and (2) the engraftment of encapsulated murine beta-cells in allo- and autoimmune settings.

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