Open AccessPig Pancreas Anatomy: Implications for Pancreas Procurement, Preservation, and Islet Isolation
Author(s) -
Joana Ferrer,
William E. Scott,
Bradley P. Weegman,
Thomas M. Suszynski,
David E.R. Sutherland,
Bernhard J. Hering,
Klearchos K. Papas
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31818bfda1
Subject(s) - islet , pancreas , anatomy , isolation (microbiology) , biology , medicine , bioinformatics , insulin
Islet transplantation is emerging as a treatment option for selected patients with type 1 diabetes. The limited human islet supply from cadavers and poor islet yield and quality remain substantial impediments to progress in the field. Use of porcine islets holds great promise for large-scale application of islet transplantation. Consistent isolation of porcine islets is dependent on advances in pancreas procurement, pancreas preservation, and islet isolation, requiring detailed knowledge of the porcine pancreatic anatomy. The primary aim of this study was to describe the vascular and ductal anatomy of the porcine pancreas to guide and improve organ preservation and enzyme perfusion.