Human Inhibitory Receptor Immunoglobulin-Like Transcript 2 Amplifies CD11b+Gr1+ Myeloid-Derived Suppressor Cells That Promote Long-Term Survival of Allografts | Zendy

Wei Zhang | Zendy; Siyuan Liang | Zendy; Juan Wu | Zendy; Anatolij Horuzsko | Zendy

Open Access

Human Inhibitory Receptor Immunoglobulin-Like Transcript 2 Amplifies CD11b+Gr1+ Myeloid-Derived Suppressor Cells That Promote Long-Term Survival of Allografts

Author(s) -

Wei Zhang,

Siyuan Liang,

Juan Wu,

Anatolij Horuzsko

Publication year - 2008

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e318186fccd

Subject(s) - myeloid derived suppressor cell , adoptive cell transfer , immunology , transplantation , human leukocyte antigen , receptor , antibody , population , suppressor , antigen , cancer research , biology , immune system , medicine , t cell , cancer , environmental health

The expression of human leukocyte antigen (HLA)-G during allogeneic recognition is associated with better graft acceptance. The inhibitory receptor immunoglobulin-like transcript (ILT)-2 is expressed on activated T cells and serves to shut down T-cell activation, culminating in T-cell death, or induction of anergy. One of the potential mechanisms in the immunosuppressive accomplishment of HLA-G-ILT2 interactions involves the expansion of myeloid-derived suppressor cells (MDSCs). The potential of MDSCs in transplantation has not yet been exploited.

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