Open AccessExpression of Tissue Factor and Initiation of Clotting by Human Platelets and Monocytes After Incubation With Porcine Endothelial Cells
Author(s) -
ChiaYu Lin,
Daxin Chen,
John H. McVey,
D. K. C. Cooper,
Anthony Dorling
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31818410a3
Subject(s) - tissue factor , incubation , platelet , chemistry , microbiology and biotechnology , monocyte , thromboplastin , clotting factor , immunology , biology , biochemistry , coagulation , medicine
Intravascular thrombosis remains a major barrier to successful pig-to-primate xenotransplantation. However, the precise factors initiating thrombosis are unknown. In this study, we investigated the contribution of recipient platelets and monocytes.