Open AccessAmelioration of Human Allograft Arterial Injury by Atorvastatin or Simvastatin Correlates With Reduction of Interferon-γ Production by Infiltrating T Cells
Author(s) -
Tai Yi,
Deepak A. Rao,
Paul C. Tang,
Yig Wang,
Lisa Cuchara,
Alfred L.M. Bothwell,
Christopher M. Colangelo,
George Tellides,
Jordan S. Pober,
Marc I. Lorber
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318183eefa
Subject(s) - atorvastatin , simvastatin , humanized mouse , arteriosclerosis , peripheral blood mononuclear cell , medicine , mycophenolate , immunology , interferon gamma , interferon , transplantation , cytokine , pharmacology , biology , in vitro , immune system , biochemistry
Graft arteriosclerosis (GA) is an important factor limiting long-term outcomes after organ transplantation. We have used a chimeric humanized mouse system to model this arteriopathy in human vessels, and found that the morphologic and functional changes of experimental GA are interferon (IFN)-gamma dependent. This study evaluated whether 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, described as inhibitors of IFN-gamma production, affect GA in our model.