Amelioration of Human Allograft Arterial Injury by Atorvastatin or Simvastatin Correlates With Reduction of Interferon-γ Production by Infiltrating T Cells | Zendy

Tai Yi | Zendy; Deepak A. Rao | Zendy; Paul C. Tang | Zendy; Yig Wang | Zendy; Lisa Cuchara | Zendy; Alfred L.M. Bothwell | Zendy; Christopher M. Colangelo | Zendy; George Tellides | Zendy; Jordan S. Pober | Zendy; Marc I. Lorber | Zendy

Open Access

Amelioration of Human Allograft Arterial Injury by Atorvastatin or Simvastatin Correlates With Reduction of Interferon-γ Production by Infiltrating T Cells

Author(s) -

Tai Yi,

Deepak A. Rao,

Paul C. Tang,

Yig Wang,

Lisa Cuchara,

Alfred L.M. Bothwell,

Christopher M. Colangelo,

George Tellides,

Jordan S. Pober,

Marc I. Lorber

Publication year - 2008

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e318183eefa

Subject(s) - atorvastatin , simvastatin , humanized mouse , arteriosclerosis , peripheral blood mononuclear cell , medicine , mycophenolate , immunology , interferon gamma , interferon , transplantation , cytokine , pharmacology , biology , in vitro , immune system , biochemistry

Graft arteriosclerosis (GA) is an important factor limiting long-term outcomes after organ transplantation. We have used a chimeric humanized mouse system to model this arteriopathy in human vessels, and found that the morphologic and functional changes of experimental GA are interferon (IFN)-gamma dependent. This study evaluated whether 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, described as inhibitors of IFN-gamma production, affect GA in our model.

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