Open AccessComparison of Human T Cell Repertoire Generated in Xenogeneic Porcine and Human Thymus Grafts
Author(s) -
Ichiro Shimizu,
Yasuhiro Fudaba,
Akira Shimizu,
YongGuang Yang,
Megan Sykes
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e318182d47a
Subject(s) - repertoire , biology , microbiology and biotechnology , immunology , anatomy , art , literature
Xenogeneic thymus transplantation is an effective approach to achieving T cell tolerance across highly disparate xenogeneic species barriers. We have previously demonstrated that phenotypically normal, specifically tolerant human T cells are generated in porcine thymic grafts. In this study, we assessed the diversity of the human T cell repertoire generated in porcine thymic xenografts. We also examined the ability of porcine thymus grafts to coexist with human thymus grafts.