Improvement of Canine Islet Yield by Donor Pancreas Infusion With a p38MAPK Inhibitor | Zendy

T. Ito | Zendy; Keiko Omori | Zendy; Jeffrey Rawson | Zendy; Иван Тодоров | Zendy; Sadaki Asari | Zendy; Akio Kuroda | Zendy; Jonathan Shintaku | Zendy; Shin Itakura | Zendy; Kevin Ferreri | Zendy; Fouad Kandeel | Zendy; Yoko Mullen | Zendy

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Improvement of Canine Islet Yield by Donor Pancreas Infusion With a p38MAPK Inhibitor

Author(s) -

T. Ito,

Keiko Omori,

Jeffrey Rawson,

Иван Тодоров,

Sadaki Asari,

Akio Kuroda,

Jonathan Shintaku,

Shin Itakura,

Kevin Ferreri,

Fouad Kandeel,

Yoko Mullen

Publication year - 2008

Publication title -

transplantation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.45

H-Index - 204

eISSN - 1534-6080

pISSN - 0041-1337

DOI - 10.1097/tp.0b013e31817ef6c9

Subject(s) - islet , pancreas , endocrinology , medicine , beagle , viaspan , biology , glucagon , transplantation , andrology , insulin

The activation of p38 mitogen-activated protein kinases (MAPK) is implicated in cold ischemia-reperfusion injury of donor organs. The islet isolation process, from pancreas procurement through islet collection, may activate p38MAPK leading to cytokine release and islet damage. This damage may be prevented by treating pancreata with a p38MAPK inhibitor (p38IH) before cold preservation.

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