Open AccessImprovement of Canine Islet Yield by Donor Pancreas Infusion With a p38MAPK Inhibitor
Author(s) -
Taihei Ito,
Keiko Omori,
Jeffrey Rawson,
Ivan Todorov,
Sadaki Asari,
Akio Kuroda,
Jonathan Shintaku,
Susumu Itakura,
Kevin Ferreri,
Fouad Kandeel,
Yoko Mullen
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31817ef6c9
Subject(s) - islet , pancreas , endocrinology , medicine , beagle , viaspan , biology , glucagon , transplantation , andrology , insulin
The activation of p38 mitogen-activated protein kinases (MAPK) is implicated in cold ischemia-reperfusion injury of donor organs. The islet isolation process, from pancreas procurement through islet collection, may activate p38MAPK leading to cytokine release and islet damage. This damage may be prevented by treating pancreata with a p38MAPK inhibitor (p38IH) before cold preservation.