Open AccessThe Use of the Papworth Cocktail is Detrimental to Steatotic Livers After Ischemia-Reperfusion Injury
Author(s) -
Justin D. Ellett,
Zachary Evans,
Jennifer H. Fiorini,
Ryan N. Fiorini,
Julia K. Haines,
Michael G. Schmidt,
Kenneth D. Chavin
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31817b900f
Subject(s) - ischemia , medicine , reperfusion injury , endocrinology , hormone , methylprednisolone , homeostasis
Hormonal resuscitation, specifically administration of levothyroxine (T4) and methylprednisolone (steroid, i.e., the "T4 Protocol") in organ transplant donors, is becoming increasingly used. Previous studies have shown that this maximizes the number of usable organs by reducing metabolic disturbances post-brain death. However, anecdotal evidence has shown that steatotic livers are adversely affected by this protocol. Therefore, we sought to investigate the hypothesis that the use of T4 and steroid is detrimental to steatotic livers in a model of total hepatic warm ischemia-reperfusion (I/R).