Open AccessExtracellular Matrix Protein-Coated Scaffolds Promote the Reversal of Diabetes After Extrahepatic Islet Transplantation
Author(s) -
David M. Salvay,
Christopher B. Rives,
Xiaomin Zhang,
Fei Chen,
Dixon B. Kaufman,
William L. Lowe,
Lonnie D. Shea
Publication year - 2008
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0b013e31816fc0ea
Subject(s) - fibronectin , islet , extracellular matrix , laminin , transplantation , chemistry , microbiology and biotechnology , glycosaminoglycan , endocrinology , medicine , diabetes mellitus , biology , biochemistry
The survival and function of transplanted pancreatic islets is limited, owing in part to disruption of islet-matrix attachments during the isolation procedure. Using polymer scaffolds as a platform for islet transplantation, we investigated the hypothesis that replacement of key extracellular matrix components known to surround islets in vivo would improve graft function at an extrahepatic implantation site.