Open AccessSpecialized Proresolving Lipid Meditators Agonistic to Formyl Peptide Receptor Type 2 Attenuate Ischemia-reperfusion Injury in Rat Lung
Author(s) -
Hiromi Oda,
Satona Tanaka,
Masakazu Shinohara,
Yuki Morimura,
Yuka Yokoyama,
Hidenao Kayawake,
Yoshito Yamada,
Yojiro Yutaka,
Akihiro Ohsumi,
Daisuke Nakajima,
Masatsugu Hamaji,
Toshi Menju,
Hiroshi Date
Publication year - 2022
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000003987
Subject(s) - lung , reperfusion injury , medicine , pulmonary edema , pharmacology , endogeny , ischemia
Lung ischemia-reperfusion injury (IRI) is a form of acute lung injury characterized by nonspecific alveolar damage and lung edema due to robust inflammation. Little is known about the roles of specialized proresolving lipid mediators (SPMs) in lung IRI. Therefore, we aimed to evaluate the dynamic changes in endogenous SPMs during the initiation and resolution of lung IRI and to determine the effects of SPM supplementation on lung IRI.