Open AccessDonor Hepatic Steatosis Induce Exacerbated Ischemia-Reperfusion Injury Through Activation of Innate Immune Response Molecular Pathways
Author(s) -
Ricardo C. Gehrau,
Valeria R. Mas,
Catherine I. Dumur,
Jihee L. Suh,
Ashish K. Sharma,
Helen P. Cathro,
Daniel G. Maluf
Publication year - 2015
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000857
Subject(s) - steatosis , proinflammatory cytokine , reperfusion injury , liver transplantation , transplantation , medicine , immunology , pathology , ischemia , andrology , inflammation
Severe liver steatosis is a known risk factor for increased ischemia-reperfusion injury (IRI) and poor outcomes after liver transplantation (LT). This study aimed to identify steatosis-related molecular mechanisms associated with IRI exacerbation after LT.