Open AccessMonitoring of Allogeneic Islet Grafts in Nonhuman Primates Using MRI
Author(s) -
Ping Wang,
Christian Schuetz,
Prashanth Vallabhajosyula,
Zdravka Medarova,
Aseda Tena,
Lingling Wei,
Kazuhiko Yamada,
Shumin Deng,
James F. Markmann,
David H. Sachs,
Anna Moore
Publication year - 2015
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000682
Subject(s) - islet , immunosuppression , medicine , in vivo , transplantation , diabetes mellitus , urology , pathology , pancreas , surgery , endocrinology , biology , microbiology and biotechnology
Information regarding the longevity of transplanted pancreatic islet grafts could provide valuable information for treatment options. In our previous studies, we showed that isolated autologous pancreatic islets could be labeled with iron oxide nanoparticles and monitored after transplantation using MRI. Here, we report on in vivo monitoring of a secondary damage that occurs at the later stages because of allogeneic immune rejection.