Open AccessIncidence, Risk Factors and Outcomes of Delayed-onset Cytomegalovirus Disease in a Large Retrospective Cohort of Lung Transplant Recipients
Author(s) -
Carlos A. Q. Santos,
Daniel C. Brennan,
Roger D. Yusen,
Margaret A. Olsen
Publication year - 2015
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000549
Subject(s) - medicine , hazard ratio , lung transplantation , transplantation , cohort , pneumonia , proportional hazards model , retrospective cohort study , pneumonitis , confidence interval , lung
Cytomegalovirus (CMV) replication and disease commonly occur in lung transplant recipients after stopping anti-CMV prophylaxis. The epidemiology of CMV disease is not well studied, given the difficulties in assembling representative study populations with prolonged follow-up. We hypothesized that delayed-onset CMV disease (>100 days after transplantation) occurs more commonly than early-onset CMV disease in lung transplant recipients, and is associated with an increased risk of death.