Open AccessDepletion of T Regulatory Cells Promotes Natural Killer Cell–Mediated Cardiac Allograft Vasculopathy
Author(s) -
Tsutomu Hirohashi,
Catharine M. Chase,
Patricia DellaPelle,
Divya Sebastian,
Evan Farkesh,
Robert B. Colvin,
Paul Russell,
Alessandro Alessandrini,
Joren C. Madsen
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000329
Subject(s) - il 2 receptor , interleukin 21 , immunology , cell , biology , pathogenesis , regulatory t cell , t cell , microbiology and biotechnology , immune system , biochemistry
A role for natural killer (NK) cells in cardiac allograft vasculopathy (CAV) was suggested by our earlier observation that CAV arises even in the absence of detectable antidonor T-cell or B-cell reactivity in parental to F1 mouse heart grafts. However, prevention of CAV in this setting required the depletion of both NK and CD4 T cells.