Open AccessCD47 Blockade Reduces Ischemia-Reperfusion Injury and Improves Outcomes in a Rat Kidney Transplant Model
Author(s) -
Yiing Lin,
Pamela T. Manning,
Jianluo Jia,
Joseph P. Gaut,
Zhenyu Xiao,
Benjamin J. Capoccia,
Chuncheng Chen,
Ronald R. Hiebsch,
Gundumi A. Upadhya,
Thalachallour Mohanakumar,
William A. Frazier,
William C. Chapman
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000252
Subject(s) - blockade , medicine , reperfusion injury , ischemia , cd47 , kidney transplant , acute kidney injury , kidney , kidney transplantation , cardiology , anesthesia , receptor
Ischemia-reperfusion injury (IRI) significantly contributes to delayed graft function and inflammation, leading to graft loss. Ischemia-reperfusion injury is exacerbated by the thrombospondin-1-CD47 system through inhibition of nitric oxide signaling. We postulate that CD47 blockade and prevention of nitric oxide inhibition reduce IRI in organ transplantation.