Open AccessDevelopment of Antidonor Antibody Directed Toward Non–Major Histocompatibility Complex Antigens in Tolerant Animals
Author(s) -
Joseph R. Scalea,
Vincenzo Villani,
B. Gillon,
Joshua Weiner,
Pierre Gianello,
Nicole Turcotte,
J S Arn,
Kazuhiko Yamada,
David H. Sachs
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000249
Subject(s) - antigen , immunology , antibody , major histocompatibility complex , medicine , peripheral blood mononuclear cell , histocompatibility , miniature swine , human leukocyte antigen , biology , genetics , in vitro
The clinical significance of antibodies directed against antigens other than major histocompatibility complex (MHC) antigens is poorly understood, and there are few large animal models in which such antibodies can be examined. We studied, both retrospectively and prospectively, the development of antibodies to non-MHC antigens in tolerant miniature swine.