Open AccessEffects of ASKP1240 Combined With Tacrolimus or Mycophenolate Mofetil on Renal Allograft Survival in Cynomolgus Monkeys
Author(s) -
Lijun Song,
Anlun Ma,
Hao Dun,
Yanxin Hu,
Lin Zeng,
Jing Bai,
Guangzhou Zhang,
Fumitaka Kinugasa,
Yuji Sudo,
Yasuhiro Miyao,
Kazumichi Okimura,
Tsuyoshi Miura,
Pierre Daloze,
Huifang Chen
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000236
Subject(s) - tacrolimus , medicine , mycophenolate , pharmacology , combination therapy , calcineurin , transplantation , mixed lymphocyte reaction , kidney , mycophenolic acid , urology , immunology , immune system , t cell
Blocking the CD40-CD154 signal pathway has previously shown promise as a strategy to prevent allograft rejection. In this study, the efficacy of a novel fully human anti-CD40 monoclonal antibody-ASKP1240, administered as a monotherapy or combination therapy (subtherapeutic dose of tacrolimus or mycophenolate mofetil), on the prevention of renal allograft rejection was evaluated in Cynomolgus monkeys.