Open AccessAlleviation of Instant Blood-Mediated Inflammatory Reaction in Autologous Conditions Through Treatment of Human Islets with NF-κB Inhibitors
Author(s) -
Mazhar A. Kanak,
Morihito Takita,
Takeshi Itoh,
Jeffrey A. SoRelle,
Shyam Murali,
Faisal Kunnathodi,
Rauf Shahbazov,
Michael C. Lawrence,
Marlon F. Levy,
Bashoo Naziruddin
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000107
Subject(s) - proinflammatory cytokine , islet , xenotransplantation , in vitro , medicine , infiltration (hvac) , pancreatic islets , proinsulin , pharmacology , chemistry , transplantation , endocrinology , inflammation , immunology , insulin , biochemistry , materials science , composite material
The instant blood-mediated inflammatory response (IBMIR) has been shown as a major factor that causes damage to transplanted islets. Withaferin A (WA), an inhibitor of nuclear factor (NF) κB, was shown to suppress the inflammatory response in islets and improve syngeneic islet graft survival in mice. We investigated how treating islets with NF-κB inhibitors affected IBMIR using an in vitro human autologous blood islet model.