Open AccessLack of Cross-Sensitization Between α-1,3-Galactosyltransferase Knockout Porcine and Allogeneic Skin Grafts Permits Serial Grafting
Author(s) -
Alexander Albritton,
David A. Leonard,
AA Leto Barone,
Josh Keegan,
Christopher Mallard,
David H. Sachs,
Josef Kurtz,
Curtis L. Cetrulo
Publication year - 2014
Publication title -
transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.45
H-Index - 204
eISSN - 1534-6080
pISSN - 0041-1337
DOI - 10.1097/tp.0000000000000093
Subject(s) - sensitization , galactosyltransferase , grafting , skin transplantation , medicine , transplantation , skin grafting , immunology , biology , surgery , chemistry , biochemistry , organic chemistry , enzyme , polymer
The current standard of care for burns requiring operative treatment consists of early burn excision and autologous split-thickness skin grafting. However, in large burns, sufficient donor sites may not be available to achieve total coverage, necessitating temporary coverage with allogeneic human cadaver skin grafts or synthetic skin substitutes. A previous study from this laboratory demonstrated that skin grafts from alpha-1,3 galactosyltransferase knockout (GalT-KO) miniature swine enjoyed survival comparable to that of allogeneic skin grafts in baboons.