Open AccessIn-Depth Characterization of the Effects of Cigarette Smoke Exposure on the Acute Trauma Response and Hemorrhage in Mice
Author(s) -
Clair Hartmann,
Michael Gröger,
Jan-Philipp Noirhomme,
Angelika Scheuerle,
Peter Möller,
Ulrich Wachter,
Markus HuberLang,
Benedikt Nußbaum,
Birgit Jung,
Tamara Merz,
Oscar McCook,
Sandra Kress,
Bettina Stahl,
Enrico Calzia,
Michael Georgieff,
Peter Radermacher,
Martin Wepler
Publication year - 2019
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000001115
Subject(s) - medicine , lung , shock (circulatory) , inflammation , resuscitation , organ dysfunction , systemic inflammation , anesthesia , multiple organ dysfunction syndrome , sepsis
Hemorrhagic shock accounts for a large amount of trauma-related mortality. The severity of trauma can be further aggravated by an additional blunt chest trauma (TxT), which independently contributes to mortality upon the development of an acute lung injury (ALI). Besides, cigarette smoke (CS) exposure before TxT enhanced posttraumatic inflammation, thereby aggravating ALI. We therefore aimed to characterize the impact of an acute and/or chronic lung injury on organ dysfunction in a murine model of traumatic hemorrhagic shock (HS).