Open AccessCaffeine Improves Heart Rate Without Improving Sepsis Survival
Author(s) -
Gustavo Bauzá,
Daniel G. Remick
Publication year - 2015
Publication title -
shock
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000399
Subject(s) - caffeine , sepsis , medicine , saline , tumor necrosis factor alpha , adenosine , immune system , adenosine receptor antagonist , pharmacology , receptor , cytokine , receptor antagonist , adenosine receptor , antagonist , immunology , agonist
Caffeine is consumed on a daily basis for its nervous system stimulant properties and is a global adenosine receptor antagonist. Because adenosine receptors have been found to play a major role in regulating the immune response to a septic insult, we investigated if caffeine consumption prior to a septic insult would alter immunological and physiological responses, as well as survival.