Open AccessPhysiologic Variability at the Verge of Systemic Inflammation
Author(s) -
Georg N. Herlitz,
Renee L. Arlow,
Nora Cheung,
Susette M. Coyle,
Benjamin Griffel,
Marie A. Macor,
Stephen F. Lowry,
Steve E. Calvano,
Stephen C. Gale
Publication year - 2015
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000276
Subject(s) - heart rate variability , medicine , heart rate , systemic inflammation , inflammation , placebo , tumor necrosis factor alpha , endogeny , lipopolysaccharide , interleukin 6 , blood pressure , pathology , alternative medicine
Human injury or infection induces systemic inflammation with characteristic neuroendocrine responses. Fluctuations in autonomic function during inflammation are reflected by beat-to-beat variation in heart rate, termed heart rate variability (HRV). In the present study, we determine threshold doses of endotoxin needed to induce observable changes in markers of systemic inflammation, investigate whether metrics of HRV exhibit a differing threshold dose from other inflammatory markers, and investigate the size of data sets required for meaningful use of multiscale entropy (MSE) analysis of HRV.