Open AccessIsoproternenol Increases Vascular Volume Expansion And Urinary Output After a Large Crystalloid Bolus in Healthy Volunteers
Author(s) -
Sven Asmussen,
Michael Salter,
Donald S. Prough,
George C. Kramer,
Christer Svensén,
Melinda SheffieldMoore,
Michael P. Kinsky
Publication year - 2014
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000233
Subject(s) - cardiac output , bolus (digestion) , medicine , interstitial fluid , hemodynamics , perfusion , blood volume , anesthesia , saline , body water , oncotic pressure , body weight , albumin
The primary goal of fluid therapy is to maintain fluid homeostasis. Commonly used isotonic crystalloids are only marginally effective and contribute to fluid excess syndrome. In patients with decreased cardiovascular reserve, fluid therapy alone is not sufficient to maintain end-organ perfusion. Therefore, inotropes or vasoactive drugs are used to supplement fluid infusion. Recent animal data suggest that coinfusion of adrenergic agents modulate the distribution of fluid between the vascular and extravascular/interstitial compartments after a fluid bolus. We sought to determine if this effect would translate in humans by coadministering a β-adrenergic agonist with fluid.