Open AccessElectroporation-Mediated Gene Delivery of Na+,K+-ATPase, and ENaC Subunits to the Lung Attenuates Acute Respiratory Distress Syndrome in a Two-Hit Porcine Model
Author(s) -
Bryanna Emr,
Somnath C. Roy,
Michaela KollischSingule,
Louis A. Gatto,
Michael Barravecchia,
Xin Lin,
Jennifer L. Young,
Guirong Wang,
Jiao Liu,
Joshua Satalin,
Kathy Snyder,
Gary F. Nieman,
David A. Dean
Publication year - 2015
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000228
Subject(s) - lung , ards , bronchoalveolar lavage , medicine , electroporation , anesthesia , pathology , andrology , biology , biochemistry , gene
Acute respiratory distress syndrome (ARDS) is a common cause of organ failure with an associated mortality rate of 40%. The initiating event is disruption of alveolar-capillary interface causing leakage of edema into alveoli.