Open AccessInterleukin 10 Overexpression Alters Survival in the Setting of Gram-Negative Pneumonia Following Lung Contusion
Author(s) -
Vladislav Dolgachev,
Bin Yu,
Lei Sun,
Thomas P. Shanley,
Krishnan Raghavendran,
Mark R. Hemmila
Publication year - 2014
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000123
Subject(s) - bronchoalveolar lavage , lung , pneumonia , medicine , pathology , inflammation , cytokine , interleukin , immunology
Lung contusion injury produces a vulnerable window within the inflammatory defenses of the lung that predisposes the patient to pneumonia. Interleukin 10 (IL-10) is a known anti-inflammatory mediator produced by macrophages and capable of downregulating acute lung inflammation. We investigated the impact of increased levels of IL-10 within the lung on survival and the host response to trauma in the setting of lung contusion (LC) and gram-negative pneumonia.