Open AccessCreating a Prosurvival Phenotype Through a Histone Deacetylase Inhibitor in a Lethal Two-Hit Model
Author(s) -
Zhengcai Liu,
Yongqing Li,
Chong Wang,
Danielle K. DePeralta,
Xiuzhen Duan,
Baoling Liu,
Ihab Halaweish,
Peter L. Zhou,
Hasan B. Alam
Publication year - 2014
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000074
Subject(s) - histone deacetylase inhibitor , valproic acid , medicine , pharmacology , h&e stain , myeloperoxidase , histone deacetylase , tumor necrosis factor alpha , septic shock , saline , immunology , inflammation , sepsis , chemistry , immunohistochemistry , epilepsy , histone , biochemistry , psychiatry , gene
Hemorrhagic shock (HS) can initiate an exaggerated systemic inflammatory response and multiple organ failure, especially if followed by a subsequent inflammatory insult ("second hit"). We have recently shown that histone deacetylase inhibitors can improve survival in rodent models of HS or septic shock, individually. In the present study, we examined whether valproic acid (VPA), a histone deacetylase inhibitor, could prolong survival in a rodent "two-hit" model: HS followed by septic shock from cecal ligation and puncture (CLP).