Open AccessPrehospital Hypertonic Saline Resuscitation Attenuates the Activation and Promotes Apoptosis of Neutrophils in Patients With Severe Traumatic Brain Injury
Author(s) -
Wolfgang G. Junger,
Shawn G. Rhind,
Sandro Rizoli,
Joseph Cuschieri,
Andrew J. Baker,
Pang N. Shek,
David B. Hoyt,
Eileen M. Bulger
Publication year - 2013
Publication title -
shock
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.095
H-Index - 117
eISSN - 1540-0514
pISSN - 1073-2322
DOI - 10.1097/shk.0000000000000038
Subject(s) - hypertonic saline , resuscitation , medicine , degranulation , apoptosis , saline , traumatic brain injury , tonicity , respiratory burst , anesthesia , immunology , chemistry , receptor , biochemistry , psychiatry
Activation of polymorphonuclear neutrophils (PMNs) is thought to contribute to traumatic brain injury (TBI). Since hypertonic fluids can inhibit PMN activation, we studied whether hypertonic fluid resuscitation can reduce excessive PMN activation in TBI patients.