Open AccessSingle-Nucleotide Polymorphisms in TrkB and Risk for Depression
Author(s) -
Valeriya Avdoshina,
Italo Mocchetti,
Chenglong Liu,
Mary Young,
Kathryn Anastos,
Mardge H. Cohen,
Howard Crystal,
Celeste Leigh Pearce,
Elizabeth T. Golub,
Rochelle E. Tractenberg
Publication year - 2013
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3182a468e9
Subject(s) - tropomyosin receptor kinase b , single nucleotide polymorphism , depression (economics) , neurotrophic factors , brain derived neurotrophic factor , polymorphism (computer science) , allele , medicine , neurotrophin , risk factor , biology , genetics , psychology , receptor , gene , genotype , economics , macroeconomics
Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75 (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75 genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.