Open AccessPrecise Determination of Time to Reach Viral Load Set Point After Acute HIV-1 Infection
Author(s) -
Xiaojie Huang,
Hui Chen,
Wei Li,
Haiying Li,
Xia Jin,
Alan S. Perelson,
Zoë Fox,
Tong Zhang,
Xiao-Ning Xu,
Hao Wu
Publication year - 2012
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31827146e0
Subject(s) - viral load , set point , set (abstract data type) , medicine , human immunodeficiency virus (hiv) , clinical endpoint , immunology , point (geometry) , virology , statistics , mathematics , computer science , clinical trial , geometry , control engineering , engineering , programming language
The HIV viral load set point has long been used as a prognostic marker of disease progression and more recently as an end-point parameter in HIV vaccine clinical trials. The definition of set point, however, is variable. Moreover, the earliest time at which the set point is reached after the onset of infection has never been clearly defined.