Open AccessThe Interrelated Transmission of HIV-1 and Cytomegalovirus During Gestation and Delivery in the Offspring of HIV-Infected Mothers
Author(s) -
Woottichai Khamduang,
Gonzague Jourdain,
Wasna Sirirungsi,
Prapaisri Layangool,
Suparat Kanjanavanit,
Pornsuda Krittigamas,
Karin Pagdi,
Rosalin Somsamai,
Surat Siritakan,
Temsiri Hinjiranandana,
Wanna Ardonk,
Suchat Hongsiriwon,
Sirisak Nanta,
Thitiporn Borkird,
Marc Lallemant,
Kenneth McIntosh,
Nicole NgoGiangHuong
Publication year - 2011
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e31822d0433
Subject(s) - cytomegalovirus , in utero , transmission (telecommunications) , offspring , human cytomegalovirus , medicine , betaherpesvirinae , gestation , immunology , logistic regression , pregnancy , human immunodeficiency virus (hiv) , viral disease , lentivirus , virology , herpesviridae , biology , virus , fetus , electrical engineering , genetics , engineering
Our objective was to analyze, in formula-fed infants, correlates of HIV mother-to-child transmission, including cytomegalovirus (CMV) infection. HIV-infected infants were matched with HIV uninfected by maternal HIV RNA in a case-control design. Infant CMV infection was determined by CMV IgG at 18 months and timed by earlier CMV IgM or CMV DNA. Correlations were assessed using logistic regression. In utero HIV infection was independently associated with congenital CMV infection (P = 0.01), intrapartum HIV infection with congenital-plus-intrapartum/neonatal CMV infection (P = 0.01), and overall HIV with overall CMV infection (P = 0.001), and prematurity (P = 0.004). Congenital and acquired CMV infections are strong independent correlates of mother-to-child HIV transmission.