Open AccessVaccine-Induced HIV-Specific CD8+ T Cells Utilize Preferential HLA Alleles and Target-Specific Regions of HIV-1
Author(s) -
David Friedrich,
Emilie Jalbert,
Warren Dinges,
John Sidney,
Alessandro Sette,
Yunda Huang,
M. Juliana McElrath,
Helen Horton
Publication year - 2011
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e318228f992
Subject(s) - avidity , allele , human leukocyte antigen , immunodominance , cd8 , biology , virology , hiv vaccine , t cell , immunology , lentivirus , cytotoxic t cell , antigen , human immunodeficiency virus (hiv) , immune system , genetics , gene , vaccine trial , viral disease , in vitro
Most T cell-based HIV-1 vaccine candidates induce responses of limited breadth for reasons that are unclear. We evaluated vaccine-induced T-cell responses in individuals receiving an HIV-1 recombinant adenoviral vaccine. Certain HLA alleles (B27, B57, B35, and B14) are preferentially utilized to mount HIV-specific responses, whereas other alleles (A02 and B07) are rarely utilized (P < 0.001). This preference seems due to 4 following factors individually or in combination: higher affinity of specific peptides to specific HLA alleles; higher avidity of T-cell receptor; HLA and peptide interaction; and/or higher surface expression of certain HLA. Thus, HLA immunodominance plays a substantial role in vaccine-induced T-cell responses.