Open AccessEarly Virologic Failure and the Development of Antiretroviral Drug Resistance Mutations in HIV-Infected Ugandan Children
Author(s) -
Theodore Ruel,
Moses R. Kamya,
Pelin Li,
William Pasutti,
Edwin D. Charlebois,
Teri Liegler,
Grant Dorsey,
Philip J. Rosenthal,
Diane V. Havlir,
Joseph K. Wong,
Jane Achan
Publication year - 2011
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181fbcbf7
Subject(s) - human immunodeficiency virus (hiv) , antiretroviral drug , drug resistance , virology , medicine , hiv drug resistance , drug , lentivirus , antiretroviral therapy , immunology , viral load , viral disease , biology , genetics , pharmacology
Without virologic testing, HIV-infected African children starting antiretroviral (ARV) therapy are at risk for undetected virologic failure and the development of ARV resistance. We sought to determine the prevalence of early virologic failure (EVF), to characterize the evolution of ARV-resistance mutations and to predict the impact on second-line therapy.