Open AccessMeasurement of Naive CD4 Cells Reliably Predicts Potential for Immune Reconstitution in HIV
Author(s) -
Timothy W. Schacker,
Ronald J. Bosch,
Kara Bennett,
Richard B. Pollard,
Gregory K. Robbins,
Ann C. Collier,
Roy M. Gulick,
John Spritzler,
Donna Mildvan
Publication year - 2010
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181c96520
Subject(s) - immunology , logistic regression , viral load , medicine , immune system , naive t cell , pathogenesis , drug naïve , immunity , human immunodeficiency virus (hiv) , t cell , cd4 t cell , t cell receptor , drug , psychiatry
Pathogenesis studies show that naive CD4 cells are preferentially depleted in lymphoid tissues during HIV infection, and studies of advanced patients suggest levels of naive CD4 cells in blood correlate to total CD4 cells after starting antiretroviral therapy (ARV). We hypothesized that measuring naive CD4 cells in blood in people at earlier stages of disease would identify those at highest risk for poor CD4 reconstitution who may benefit from earlier initiation of ARV.