Open AccessMitochondrial DNA Haplogroups Influence Lipoatrophy After Highly Active Antiretroviral Therapy
Author(s) -
Sher L. Hendrickson,
Lawrence A. Kingsley,
Eduardo RuizPesini,
Jason C. Poole,
Lisa P. Jacobson,
Frank J. Palella,
Jay H. Bream,
Douglas C. Wallace,
Stephen J. O’Brien
Publication year - 2009
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0b013e3181a324d6
Subject(s) - lipoatrophy , human mitochondrial dna haplogroup , odds ratio , haplogroup , buttocks , multicenter aids cohort study , medicine , mitochondrial dna , mitochondrial toxicity , gastroenterology , genotype , haplotype , viral load , antiretroviral therapy , biology , immunology , surgery , genetics , human immunodeficiency virus (hiv) , toxicity , gene
Although highly active antiretroviral therapy (HAART) has been extremely effective in lowering AIDS incidence among patients infected with HIV, certain drugs included in HAART can cause serious mitochondrial toxicities. One of the most frequent adverse events is lipoatrophy, which is the loss of subcutaneous fat in the face, arms, buttocks, and/or legs as an adverse reaction to nucleoside reverse transcriptase inhibitors. The clinical symptoms of lipoatrophy resemble those of inherited mitochondrial diseases, which suggest that host mitochondrial genotype may play a role in susceptibility. We analyzed the association between mitochondrial haplogroup and severity of lipoatrophy in HIV-infected European American patients on HAART in the Multicenter AIDS cohort Study and found that mitochondrial haplogroup H was strongly associated with increased atrophy [arms: P = 0.007, odds ratio (OR) = 1.77, 95% confidence interval (CI) = 1.17 to 2.69; legs: P = 0.037, OR = 1.54, 95% CI = 1.03 to 2.31; and buttocks: P = 0.10, OR = 1.41 95% CI = 0.94 to 2.12]. We also saw borderline significance for haplogroup T as protective against lipoatrophy (P = 0.05, OR = 0.52, 95% CI = 0.20 to 1.00). These data suggest that mitochondrial DNA haplogroup may influence the propensity for lipoatrophy in patients receiving nucleoside reverse transcriptase inhibitors.